AGENDA

Continental Breakfast available at 8:15 

9:00 - 9:20: Introduction, Overview of Center, Vision & Mission - Nevan Krogan

PROJECT 1

9:20 - 9:40: Strain specific differences of HIV-1 Vif mutational tolerance in the context of Apobec3 restriction: Caroline Langley (Emerman Lab) [15 mins 5 mins for questions]

9:40 - 10:00: Dissecting the role of the molecular-arms race and RNA in Vif mediated ubiquitination of APOBEC3G: Leandrew Dailey (Gross Lab) [15 mins 5 mins for questions]

PROJECT 2

10:00 - 10:20: Rev Exposes the Many Faces of Crm1: Amber Smith (Frankel Lab) [15 mins 5 mins for questions]

10:20 - 10:40: Coffee Break [20 mins]

10:40 - 11:00: Nanoparticle Delivery of Tat Synergizes With Latency Reversal Agents to Express HIV Antigen: Shane Falcinelli (Archin Lab) [15 mins 5 mins for questions]

PROJECT 3

11:00 - 11:20: Targeting Transcriptional Elongation in HIV-1 Latency Reversal: William Cisneros (Hultquist Lab) [15 mins 5 mins for questions]                         

11:20 - 11:40: CPSF6 regulates the antiviral response to HIV-1 infection through transcriptional reprogramming: Daphne Cornish (Hultquist Lab) [15 mins 5 mins for questions]

11:40 - 1:00: Photo break and Lunch [1 hour 20 mins]

COMPUTATIONAL CORE

1:00 - 1:20: Prediction of cross-species adaptations through integrative modeling of host-virus interfaces: Nicholas Chesarino and Ignacia Echeverria [15 mins 5 mins for questions]

PROTEOMICS CORE

1:20 - 1:35: Mapping Global Landscape of Protein Complexes in CD4 T cells and Macrophages using Co-Fractionation MS: Monita Muralidharan (Krogan Lab) [10 mins 5 mins for questions]

GENETICS CORE

1:35 - 1:50: Systematic Discovery of Pro- and Anti-HIV Host Factors in Primary Human CD4 T Cells: Ujjwal Rathore (Marson Lab) [10 mins 5 mins for questions]

STRUCTURAL BIOLOGY CORE

1:50 - 2:05: Rare Antibody Phage Isolation and Discrimination (RAPID) enables identification of antibodies against challenging targets: Dong Hee Chung (Craik Lab) [10 mins 5 mins for questions]

2:05 - 2:25: Coffee break [20 mins]

DEVELOPMENTAL CORE

2:25 - 2:35: HARC Center Developmental Core Overview: Robyn Kaake [10 mins]

HARC Collaborative Developmental Award Research Talk

2:35 - 2:50: Neuro-immune modeling of HIV-induced peripheral neuropathy identifies HIV-1 Vpr as a driver of neurotoxicity: Carina Sandoval (Su, Fregoso, Bouhaddou lab) [10 mins 5 mins for questions]

HARC Mentored Scientist Award Research Talk

2:50 - 3:05: HIV-1 regulates immune activation through Vif-mediated degradation of HUWE1: Kathryn Jackson Jones (Hultquist Lab) [10 mins 5 mins for questions]

3:05 - 3:15: Structural dynamics of human endogenous FASN: Wooyoung Choi (Cheng Lab) [10 mins 5 mins for questions]

TRAINEE FLASH TALKS

3:15 - 3:20: Exploring the role of CCR5 variants in HIV-1 infection: Yujin Lee (Hultquist Lab) [3 mins 2 mins for questions]

3:20 - 3:25: Red-14: A Small Molecule Inhibitor Of The Super Elongation Complex As A Novel Latency Reversal Agent: Ariel Halle (Hultquist Lab) [3 mins 2 mins for questions]

3:25 - 3:30 Capturing endogenous virus-host protein interactions with MS: Reanna Lao (Krogan Lab) [3 mins 2 mins for questions]

3:30 - 5:00: Poster session [1.5 hour] SAB members can take a look at posters from 3:30 - 4:00 pm.

In parallel:

4:00 - 4:30: Scientific Advisory Board (SAB) meets with NIH/NIAID Program Officer David McDonald

4:30 - 5:00 SAB & Program Officer meet with Director, Nevan Krogan

5:00 - 6:00 Trainee Reception at Log Cabin

5:00 - 8:00 Faculty and SAB members Dinner at Sessions    

Join via HARC SAB Zoom Link:
https://ucsf.zoom.us/j/93365123696?pwd=WTFjbUxTOHlZWW1KTW5zR3pjRnA2QT09
Meeting ID: 933 6512 3696
Password: 724582