PROJECT 7: CHARACTERIZATION OF SIUPER RESTRICTION FACTORS AND PREDICTION OF HOST-HIV INTERFACES
The human genome has evolved a constellation of antiviral genes with the potential to target HIV. However, HIV has adapted to grow in human cells, in part, because it has adapted to escape this human antiviral inhibition. In this project, the evolutionary signatures of past interactions of lentiviruses with their primate hosts will be used to guide functional and structural studies of HIV-host protein interactions. This project will provide a means to prioritize candidate host proteins based on their evolutionary signatures as well as identifying novel genes for study.