Core co-Leaders: Alexander Marson & Jennifer Doudna

The HARC Center CRISPR Core continues to push forward advanced technologies we have developed to enhance and complement our innovative structural biology and proteomic efforts. Specifically, the Core contributes to progress on Projects 1-7 by: generating a functional HIV-Host interactome map in primary human T cells, testing the function of specific residues in HIV-host protein complexes with cell editing, and performing affinity-tagging of endogenous host factors in primary human T cells.