Rev
Tat
Vif
Integrase
Proteomics
Env
Nef

Publications

A selected list of recent publications. For more publications, see individual HARC Center members' websites.

Alian, A., Griner, S.L., Chiang, V., Tsiang, M., Jones, G., Birkus, G., Geleziunas, R., Leavitt, A.D. and Stroud, R.M. (2009). Catalytically-active complex of HIV-1 integrase with a viral DNA substrate binds anti-integrase drugs. Proc. Natl. Acad. Sci. USA, 106, 8192-8197.

Barboric, M., Chen, H., Lenassi, T., Johansen, E.B., Guo, S. and Peterlin, B.M. (2009). 7SK snRNP/P-TEFb couples transcription elongation with alternative splicing and is essential for vertebrate development.  Proc. Natl. Acad. Sci. USA, 106, 7798-803

Bushman, F.D., Malani, N., Fernandes, J., D’Orso, I., Cagney, G., Diamond, T.L., Zhou, H., Hazuda, D.J., Espeseth, A.S., Koing, R., Bandyopadhyay, S., Ideker, T., Goff, S., Krogan, N., Frankel, A., Young, J.A.T., and Chanda, S.K. (2009) Host cell factors in HIV replication: meta-analysis of genome-wide studies.  PLoS Path. 5, e1000437.

Contreras, X., Schweneker, M., Chen, C.S., McCune, J.M, Deeks, S.G., Martin, J. and Peterlin, B.M. (2009).  Suberoylanilide hyroxamic acid reactivates HIV from latently infected cells. J. Biol. Chem. 284, 6872-9.

D'Orso I. and Frankel A.D. (2009) Tat acetylation modulates assembly of a viral-host RNA-protein transcription complex, Proc. Natl. Acad. Sci. USA 106, 3101-3106.

2008:

Aguiar, R.S. and Peterlin, B.M. (2008), APOBEC3 proteins and reverse transcription. Virus Res. Vol. 134, p. 74-85.

Blazek, D. and Peterlin, B.M. (2008), Tat-SIRT1 Tango. Molecular Cell, Vol. 29, p. 539-540.

Daugherty, M.D., D'Orso, I. and Frankel, A.D. (2008) A solution to limited genomic capacity: Using adaptable binding surfaces to assemble the functional HIV Rev oligomer on RNA. Molecular Cell, Vol. 31, p. 824-834.

D'Orso I., Grunwell, J.R., Nakamura, R.L., Das, C. and Frankel A.D. (2008) Targeting Tat inihibitors in the assembly of HIV-1 transcription complexes, J. Virol. 82, 9492-9504.

Farady, C.J., Egea, P.F., Schneider, E.L., Darragh, M.R. and Craik, C.S. (2008) Structure of an Fab-Protease complex reveals a highly specific non-canonical mechanism of inhibition. J. Mol. Biol., Vol. 380, p. 351-360.

2007:

R.S. Aguiar, N. Lovsin, A. Tanuri and B.M. Peterlin (2007), Vpr.A3A Chimera inhibits HIV Replication. J. Biol. Chem., Vol. 283, p. 2518-2525.

S.A. Dames, A. Schonichen, A. Svhulte, M. Barboric, B.M. Peterlin, S. Grzesiek and M. Geyer (2007), Structure of the Cyclin T binding domain of Hexim1 and molecular basis for its recognition of P-TEFb. PNAS, 104, p. 14312-17

Barboric, M. Yik, J.. Czudnochowski, M., Yang, Z, Chen, R., Contreras, X., Geyer, M., Peterlin, B.M. and Zhou, Q. (2007) Tat competes with HEXIM1 to increase the active pool of P-TEFb for HIV-1 transcription. Nucleic Acids Res. 35: 2003-2012.

Contreras, X., Barboric, M., Lenassi, T. and Peterlin, B.M. (2007). HMBA releases P-TEFb from HEXIM1 and 7SK snRNA via PI3K/Akt and activates HIV transcription. PLoS Pathog 3: 1459-1469.