Rev
Tat
Vif
Integrase
Proteomics
Env
Nef

HIV-Host Complexes

Throughout the HIV life cycle, viral-host complexes play an integral role in the biology of the virus. Assemblies range from binary protein-protein and protein-nucleic acid complexes to much larger multicomponent complexes. High-resolution structures of these complexes offer the potential for targeted intervention strategies in the treatment of AIDS.

The HARC Center primarily focuses on four regulatory and accessory proteins involved in the transmission of the viral genetic information from viral RNA to DNA to mRNA: Rev, Tat, Vif and Integrase. We also have projects and/or collaborations on Env and Nef. We are also utilizing a proteomics approach to generate a comprehensive map of high quality, validated interactions for these proteins and others in the HIV genome.