Melanie Brewer, PhD

About

Melanie Brewer is the HARC Center Program Manager and also manages the GPS-Prot website www.gpsprot.org

Publications

  1. Fahey ME, Bennett MJ, Mahon C, Jäger S, Pache L, Kumar D, Shapiro A, Rao K, Chanda SK, Craik CS, Frankel AD, Krogan NJ. GPS-Prot: a web-based visualization platform for integrating host-pathogen interaction data. BMC Bioinformatics. 2011 Jul 22; 12:298.
  2. Li P, Huey-Tubman KE, Gao T, Li X, West AP, Bennett MJ, Bjorkman PJ. The structure of a polyQ-anti-polyQ complex reveals binding according to a linear lattice model. Nat Struct Mol Biol. 2007 May; 14(5):381-7.
  3. Bennett MJ, Sawaya MR, Eisenberg D. Deposition diseases and 3D domain swapping. Structure. 2006 May; 14(5):811-24.
  4. Davis MI, Bennett MJ, Thomas LM, Bjorkman PJ. Crystal structure of prostate-specific membrane antigen, a tumor marker and peptidase. Proc Natl Acad Sci U S A. 2005 Apr 26; 102(17):5981-6.
  5. Bennett MJ, Eisenberg D. The evolving role of 3D domain swapping in proteins. Structure. 2004 Aug; 12(8):1339-41.
  6. Bennett MJ, Huey-Tubman KE, Herr AB, West AP, Ross SA, Bjorkman PJ. A linear lattice model for polyglutamine in CAG-expansion diseases. Proc Natl Acad Sci U S A. 2002 Sep 03; 99(18):11634-9.
  7. West AP, Giannetti AM, Herr AB, Bennett MJ, Nangiana JS, Pierce JR, Weiner LP, Snow PM, Bjorkman PJ. Mutational analysis of the transferrin receptor reveals overlapping HFE and transferrin binding sites. J Mol Biol. 2001 Oct 19; 313(2):385-97.
  8. West AP, Bennett MJ, Sellers VM, Andrews NC, Enns CA, Bjorkman PJ. Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE. J Biol Chem. 2000 Dec 08; 275(49):38135-8.
  9. Bennett MJ, Lebrón JA, Bjorkman PJ. Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor. Nature. 2000 Jan 06; 403(6765):46-53.
  10. Lebrón JA, Bennett MJ, Vaughn DE, Chirino AJ, Snow PM, Mintier GA, Feder JN, Bjorkman PJ. Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor. Cell. 1998 Apr 03; 93(1):111-23.
  11. Jez JM, Bennett MJ, Schlegel BP, Lewis M, Penning TM. Comparative anatomy of the aldo-keto reductase superfamily. Biochem J. 1997 Sep 15; 326 ( Pt 3):625-36.
  12. Bennett MJ, Albert RH, Jez JM, Ma H, Penning TM, Lewis M. Steroid recognition and regulation of hormone action: crystal structure of testosterone and NADP+ bound to 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase. Structure. 1997 Jun 15; 5(6):799-812.
  13. Schlunegger MP, Bennett MJ, Eisenberg D. Oligomer formation by 3D domain swapping: a model for protein assembly and misassembly. Adv Protein Chem. 1997; 50:61-122.
  14. Penning TM, Bennett MJ, Smith-Hoog S, Schlegel BP, Jez JM, Lewis M. Structure and function of 3 alpha-hydroxysteroid dehydrogenase. Steroids. 1997 Jan; 62(1):101-11.
  15. Penning TM, Pawlowski JE, Schlegel BP, Jez JM, Lin HK, Hoog SS, Bennett MJ, Lewis M. Mammalian 3 alpha-hydroxysteroid dehydrogenases. Steroids. 1996 Sep; 61(9):508-23.
  16. Bennett MJ, Schlegel BP, Jez JM, Penning TM, Lewis M. Structure of 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase complexed with NADP+. Biochemistry. 1996 Aug 20; 35(33):10702-11.
  17. Bennett MJ, Schlunegger MP, Eisenberg D. 3D domain swapping: a mechanism for oligomer assembly. Protein Sci. 1995 Dec; 4(12):2455-68.
  18. Bennett MJ, Choe S, Eisenberg D. Refined structure of dimeric diphtheria toxin at 2.0 A resolution. Protein Sci. 1994 Sep; 3(9):1444-63.
  19. Bennett MJ, Eisenberg D. Refined structure of monomeric diphtheria toxin at 2.3 A resolution. Protein Sci. 1994 Sep; 3(9):1464-75.
  20. Bennett MJ, Choe S, Eisenberg D. Domain swapping: entangling alliances between proteins. Proc Natl Acad Sci U S A. 1994 Apr 12; 91(8):3127-31.
  21. Choe S, Bennett MJ, Fujii G, Curmi PM, Kantardjieff KA, Collier RJ, Eisenberg D. The crystal structure of diphtheria toxin. Nature. 1992 May 21; 357(6375):216-22.
  22. Fujii G, Choe SH, Bennett MJ, Eisenberg D. Crystallization of diphtheria toxin. J Mol Biol. 1991 Dec 20; 222(4):861-4.