Cryo-EM Core

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Core Leader: Yifan Cheng

The Cryo-EM Core, led by Yifan Cheng, is one of four technology cores that interact extensively with all HARC projects. The Cryo-EM Core has developed novel methods to break through the technical limitations of single particle cryo-EM to determine the structures of relatively small HIV-host protein complexes and membrane protein complexes, including novel programs, algorithms, instrumentation and development of the Fast cryo-EM method (Fab-assisted single particle cryo-EM).  Collaborative work with the Craik lab provides new methodological approaches for Fab identification and purification as well as generation of Fabs to assist in obtaining high resolution structures of HIV-host complexes and functional characterization.