Antibody Technology Core

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Core Leader: Charles Craik

Recombinant antibody (rAb) reagents including antibody fragments (Fabs), single chain Fvs (scFvs) and nanobodies have grown increasingly central to the achievement of the aims of the HARC Center. Such reagents, particularly Fabs are used routinely now to stabilize protein complexes including membrane proteins, serve as fiducial markers in single particle cryo-EM studies and act as binding partners to accelerate x-ray crystallographic studies. The goal of the antibody core is to generate Fabs, scFvs and nanobodies that bind to different conformational states of HIV accessory and regulatory proteins to enable and accelerate activities in all Projects and Cores.