Sister Centers

The HARC Center is one of three Research Centers launched in 2007 under the program for Determination of Structures of HIV/Host Complexes funded by the NIH.

The Center for Structural Biology of Cellular Host Elements in Egress, Trafficking, and Assembly of HIV (CHEETAH) is located at the University of Utah, and is headed by Wesley I. Sundquist. The Center uses computational and experimental methods to analyze HIV molecular complexes and determine how they interact with and commandeer cellular machinery to traffic throught the cell and form new virus particles. By visually reconstructing various elements of virus particle assembly and trafficking, the center aims to develop HIV into a model for studying how other human viruses interact with cellular hosts.

Utah Center Website

Center Investigators include:

• Wesley I. Sundquist, Ph.D. (University of Utah)
• Christopher P. Hill, Ph.D. (University of Utah)
• Michael S. Kay, M.D., Ph.D. (University of Utah)
• David G. Myszka, Ph.D. (University of Utah)
• Jill Trewhella, Ph.D. (University of Utah)
• Gregory A. Voth, Ph.D. (University of Utah)
• Larry Gerace, Ph.D. (Scripps Research Institute)
• Tom Hope, Ph.D. (Northwestern University)
• Grant Jensen, Ph.D. (California Institute of Technology)
• David Millar, Ph.D. (Scripps Research Institute)
• Jamie Williamson, Ph.D. (Scripps Research Institute)
• Mark Yeager, Ph.D. (Scripps Research Institute)

 

The University of Pittsburgh Center for HIV Protein Interactions (PCHPI) , led by Angela Gronenborn, specializes in developing a structure determination pipeline to image pivotal events occurring right after the virus fuses with the host cell. The Center is aimed at establishing a framework for computationally predicting important cellular partners for HIV and for experimentally validating such predictions.

Pittsburgh Center website

Center Investigators include:

• Angela Gronenborn, Ph.D. (University of Pittsburgh)
• Ronald C. Montelaro, Ph.D. (University of Pittsburgh)
• Jinwoo Ahn, Ph.D. (University of Pittsburgh)
• Christopher Aiken, Ph.D. (Vanderbilt University)
• In-Ja Byeon, Ph.D. (University of Pittsburgh)
• Judith Klein-Seetharaman, Ph.D. (University of Pittsburgh)
• Simon Watkins, Ph.D. (University of Pittsburgh)
• Joanne Yeh, Ph.D. (University of Pittsburgh)
• Peijun Zhang, Ph.D. (University of Pittsburgh)
• Dalaver Anjum, Ph.D. (University of Pittsburgh)
• Velpandi Ayyavoo, Ph.D. (University of Pittsburgh)
• Russell Salter, Ph.D. (University of Pittsburgh)
• Nicolas Sluis-Cremer, Ph.D. (University of Pittsburgh)
• Thomas Smithgall, Ph.D. (University of Pittsburgh)